---
title: What is Severe Sepsis?
description: Severe sepsis occurs when sepsis progresses, and acute organ dysfunction/failure develops.
image: https://hiacode.com/hubfs/Imported_Blog_Media/iStock-540123898-1.jpg
---

# What is Severe Sepsis?

![HIAcode](https://hiacode.com/hubfs/Logos/HIA_RGB_PrimaryLogo_Icon%20(1)_Artboard%201.png)

[HIAcode](https://hiacode.com/blog/author/hiacode)

Nov 13, 2019

[Medical Coding Tips](https://hiacode.com/blog/tag/medical-coding-tips)

![Severe Sepsis](https://hiacode.com/hubfs/Imported_Blog_Media/iStock-540123898-1.jpg)

- Share on:
- [![](https://hiacode.com/hubfs/Facebook%20svg.svg)](http://www.facebook.com/share.php?u=https://hiacode.com/blog/education/severe-sepsis-documentation-and-reporting)
- [![](https://hiacode.com/hs-fs/hubfs/twitter.png?width=32&height=32&name=twitter.png)](https://twitter.com/intent/tweet?text=I+found+this+interesting+blog+post&url=https://hiacode.com/blog/education/severe-sepsis-documentation-and-reporting)
- [![](https://hiacode.com/hubfs/LinkedIn%20svg.svg)](http://www.linkedin.com/shareArticle?mini=true&url=https://hiacode.com/blog/education/severe-sepsis-documentation-and-reporting)
- [![](https://hiacode.com/hubfs/mdi_email.svg)](mailto:?subject=Check%20out%20https://hiacode.com/blog/education/severe-sepsis-documentation-and-reporting%20&body=Check%20out%20https://hiacode.com/blog/education/severe-sepsis-documentation-and-reporting&media=https://20824215.fs1.hubspotusercontent-na1.net/hubfs/20824215/Imported_Blog_Media/iStock-540123898-1.jpg)
- ![](https://hiacode.com/hubfs/entypo_link.svg)
  
   copied

## What is Severe Sepsis?

Severe sepsis occurs when sepsis progresses and signs of organ dysfunction/failure develop. One site stated that approximately 30% of patients with severe sepsis do not survive. Patients may develop one organ dysfunction/failure, multi-system organ failure and/or septic shock. Septic shock is severe cardiovascular dysfunction with extremely low blood pressure and hypoperfusion that does not respond to intravenous fluids. If severe sepsis is not documented correctly in the medical record, it is very difficult for coders to know how to report. A physician query may be necessary to clarify that the organ dysfunction in the record is related to the sepsis, if not documented clearly.

Cryptic septic shock is another type of shock being documented. These patients have severe lactic acidosis (4.0 mM/L or greater) and clinical signs of shock. The blood pressure may be normal in patients with cryptic septic shock. ALL patients should have a serum lactate measured that present with signs of sepsis. This elevated value may alert the physician of cryptic shock.

## What Documentation is Needed to Report Severe Sepsis?

For coders, if the physician has documented severe sepsis, linked an acute organ dysfunction/failure to sepsis or the ICD-10-CM Index to Diseases directs the coder to the code for severe sepsis, it may be coded.

There are two codes for severe sepsis in ICD-10-CM that are reported in addition to the code for sepsis and any organ dysfunction/failure codes

- **R65.20—Severe sepsis without septic shock**
- **R65.21—Severe sepsis with septic shock**

Neither of these two codes are acceptable as the PDX. The ICD-10-CM Index does have instructional notes to code first the underlying infection. There are also instructional notes to use additional code to identify specific organ dysfunction. There are several organ dysfunctions listed it the ICD-10-CM Index, but this list is not an exhaustive list. A query may be necessary to clarify if the documentation is describing organ dysfunction or if the organ dysfunction is related to the diagnosis of sepsis.

To view coding examples, download our [Sepsis Coding eBook](https://hiacode.com/resources/sepsis).

[![Sepsis-no-shadow](https://no-cache.hubspot.com/cta/default/20824215/interactive-162176530190.png) ](https://hiacode.com/hs/cta/wi/redirect?encryptedPayload=AVxigLLDOXaRVjJwuP7Mvb6fLNbVI%2FjHBPtxORCApcavkK%2FR%2Fpugsq3yLdxyv%2FlGwreBDaR8ubbiMNgl94THswkVK7Vdpe2NoJuXT82wo%2FK6To2MYX7if84J%2FrTb0IZn89Ou3X27dDPC02Os1GwmMjTQXNYjzb4wfnpJY%2FtVit6d4RViuClxCXgmqw%3D%3D&webInteractiveContentId=162176530190&portalId=20824215)

*Authored by Kim Boy, RHIT, CDIP, CCS, CCS-P*

**References**  
[cancertherapyadvisor.com/home/decision-support-in-medicine/critical-care-medicine/severe-sepsis-and-septic-shock/](https://www.cancertherapyadvisor.com/home/decision-support-in-medicine/critical-care-medicine/severe-sepsis-and-septic-shock/)  
[sepsis.org/sepsis-basics/what-is-sepsis/](https://www.sepsis.org/sepsis-basics/what-is-sepsis/)  
[merckmanuals.com/professional/critical-care-medicine/sepsis-and-septic-shock/sepsis-and-septic-shock](https://www.merckmanuals.com/professional/critical-care-medicine/sepsis-and-septic-shock/sepsis-and-septic-shock)  
ICD-10-CM Official Guidelines for Coding and Reporting FY 2020  
Coding Clinic for ICD-10-CM/PCS, Third Quarter 2019: Page 17  
Coding Clinic for ICD-10-CM/PCS, Fourth Quarter 2017: Page 98-100  
Coding Clinic for ICD-10-CM/PCS, Third Quarter 2016: Page 14  
Coding Clinic for ICD-10-CM/PCS, Second Quarter 2017: Page 8-9

 

***The information contained in this coding advice is valid at the time of posting. Viewers are encouraged to research subsequent official guidance in the areas associated with the topic as they can change rapidly.***

##### [Previous](https://hiacode.com/blog/education/sepsis-series-what-is-sepsis)

<https://hiacode.com/blog/education/sepsis-series-what-is-sepsis>

### [What is Sepsis?](https://hiacode.com/blog/education/sepsis-series-what-is-sepsis)

##### [Next](https://hiacode.com/blog/education/reasons-for-denials-and-prevention-for-sepsis)

<https://hiacode.com/blog/education/reasons-for-denials-and-prevention-for-sepsis>

### [Reasons for Denials and Prevention | Sepsis Series](https://hiacode.com/blog/education/reasons-for-denials-and-prevention-for-sepsis)

Serach Blog Post

## Need to Earn CEUs?

Our coding education platform, HIAlearn.com, offers courses related to this topic and many more. Subscribe today and access more than 230 courses accepted by AHIMA for CEUs, with a selection also accepted by AAPC.

![CTA Sidebar HIAlearn logo-1](https://hiacode.com/hs-fs/hubfs/CTA%20Sidebar%20HIAlearn%20logo-1.png?width=1080&height=189&name=CTA%20Sidebar%20HIAlearn%20logo-1.png)

[![Learn More](https://no-cache.hubspot.com/cta/default/20824215/f611164b-1c02-4b86-a2aa-6033633d4569.png)](https://cta-redirect.hubspot.com/cta/redirect/20824215/f611164b-1c02-4b86-a2aa-6033633d4569)

#### Category

- [Medical Coding Tips (370)](https://hiacode.com/blog/tag/medical-coding-tips)
- [Industry News (339)](https://hiacode.com/blog/tag/industry-news)
- [Company News (23)](https://hiacode.com/blog/tag/company-news)
- [Query Tips (23)](https://hiacode.com/blog/tag/query-tips)
- [Annual Code Updates (16)](https://hiacode.com/blog/tag/annual-code-updates)
- [CDI Tips (9)](https://hiacode.com/blog/tag/cdi-tips)

### Subscribe to our Newsletter

#### Recent Blogs

<https://hiacode.com/blog/icd-10-cm-coding-for-colonoscopy-following-positive-cologuard-result>

 Jul 01, 2026

[Industry News](https://hiacode.com/blog/tag/industry-news) [Medical Coding Tips](https://hiacode.com/blog/tag/medical-coding-tips)

### [ICD-10-CM Coding for Colonosco...](https://hiacode.com/blog/icd-10-cm-coding-for-colonoscopy-following-positive-cologuard-result)

<https://hiacode.com/blog/20k-inpatient-coding-reviews-principal-diagnosis-pcs-revenue-integrity>

 Jun 24, 2026

[Industry News](https://hiacode.com/blog/tag/industry-news) [Medical Coding Tips](https://hiacode.com/blog/tag/medical-coding-tips)

### [20,000 Inpatient Reviews Revea...](https://hiacode.com/blog/20k-inpatient-coding-reviews-principal-diagnosis-pcs-revenue-integrity)

<https://hiacode.com/blog/big-changes-coming-to-cpt-coding-for-maternity-care>

 Jun 10, 2026

[Industry News](https://hiacode.com/blog/tag/industry-news) [Medical Coding Tips](https://hiacode.com/blog/tag/medical-coding-tips)

### [Big Changes Coming to CPT Codi...](https://hiacode.com/blog/big-changes-coming-to-cpt-coding-for-maternity-care)

<https://hiacode.com/blog/proactive-coding-quality-assurance>

 Jun 05, 2026

[Industry News](https://hiacode.com/blog/tag/industry-news) [Medical Coding Tips](https://hiacode.com/blog/tag/medical-coding-tips)

### [Why Being Proactive Matters in...](https://hiacode.com/blog/proactive-coding-quality-assurance)

## Related blogs from Medical Coding Tips

<https://hiacode.com/blog/icd-10-cm-coding-for-colonoscopy-following-positive-cologuard-result>

 Jul 01, 2026

[Industry News](https://hiacode.com/blog/tag/industry-news),  [Medical Coding Tips](https://hiacode.com/blog/tag/medical-coding-tips)

#### [ICD-10-CM Coding for Colonoscopy Following Positiv...](https://hiacode.com/blog/icd-10-cm-coding-for-colonoscopy-following-positive-cologuard-result)

A colonoscopy prompted by a positive Cologuar...

[ Read More](https://hiacode.com/blog/icd-10-cm-coding-for-colonoscopy-following-positive-cologuard-result)

<https://hiacode.com/blog/20k-inpatient-coding-reviews-principal-diagnosis-pcs-revenue-integrity>

 Jun 24, 2026

[Industry News](https://hiacode.com/blog/tag/industry-news),  [Medical Coding Tips](https://hiacode.com/blog/tag/medical-coding-tips)

#### [20,000 Inpatient Reviews Reveal Coding Opportuniti...](https://hiacode.com/blog/20k-inpatient-coding-reviews-principal-diagnosis-pcs-revenue-integrity)

A review of 20,805 inpatient encounters found...

[ Read More](https://hiacode.com/blog/20k-inpatient-coding-reviews-principal-diagnosis-pcs-revenue-integrity)

<https://hiacode.com/blog/big-changes-coming-to-cpt-coding-for-maternity-care>

 Jun 10, 2026

[Industry News](https://hiacode.com/blog/tag/industry-news),  [Medical Coding Tips](https://hiacode.com/blog/tag/medical-coding-tips)

#### [Big Changes Coming to CPT Coding for Maternity Car...](https://hiacode.com/blog/big-changes-coming-to-cpt-coding-for-maternity-care)

Beginning January 1, 2027, CPT will retire th...

[ Read More](https://hiacode.com/blog/big-changes-coming-to-cpt-coding-for-maternity-care)

<https://hiacode.com/blog/proactive-coding-quality-assurance>

 Jun 05, 2026

[Industry News](https://hiacode.com/blog/tag/industry-news),  [Medical Coding Tips](https://hiacode.com/blog/tag/medical-coding-tips)

#### [Why Being Proactive Matters in Coding Quality Assu...](https://hiacode.com/blog/proactive-coding-quality-assurance)

Taking a proactive approach to coding quality...

[ Read More](https://hiacode.com/blog/proactive-coding-quality-assurance)

## Subscribe to our Newsletter

Weekly medical coding tips and coding education delivered directly to your inbox.

```json
{
  "@context" : "https://schema.org",
  "@type" : "BlogPosting",
  "author" : {
    "@type" : "Person",
    "name" : "HIAcode",
    "url" : "https://hiacode.com/blog/author/hiacode"
  },
  "dateModified" : "2024-04-01T15:24:27.351Z",
  "datePublished" : "2019-11-13T05:00:00.000Z",
  "headline" : "What is Severe Sepsis?",
  "image" : [ "https://hiacode.com/hubfs/Imported_Blog_Media/iStock-540123898-1.jpg" ],
  "mainEntityOfPage" : {
    "@id" : "https://hiacode.com/blog/education/severe-sepsis-documentation-and-reporting",
    "@type" : "WebPage"
  },
  "publisher" : {
    "@type" : "Organization",
    "logo" : {
      "@type" : "ImageObject",
      "url" : "https://hiacode.com/hubfs/HIA_RGB_AlternativeLogo%20(1)%20(1).png"
    },
    "name" : "Health Information Associates"
  }
}
```