HIAcode Blog

Querying for Sepsis: Clinical Indicators, SOFA Criteria, and How to Avoid Leading Language

Written by Amanda Register, RHIT, CDIP, CCS | Jul 17, 2025 5:35:24 PM

What is Sepsis?

Sepsis is a serious, potentially life-threatening, condition where the body reacts to a localized infection and causes systemic inflammation and organ damage. Sepsis can be caused by bacterial, viral ,fungal, or other organisms that cause infection. A diagnosis of sepsis cannot be assumed based on laboratory and/or clinical criteria. Sometimes certain localized infections can have the same signs and symptoms as sepsis, but sepsis is not present. The provider must document in the medical record that the patient has a diagnosis of sepsis. However, if there are substantial clinical indicators that suggest sepsis, a query may be sent to the provider to clarify if the diagnosis of sepsis is indeed present.

How is Sepsis Diagnosed?

Sepsis is diagnosed based on clinical assessment, lab tests, and SOFA (Sequential Organ Failure Assessment) score. Clinical assessment indicators include fever, tachycardia, tachypnea, hypotension, potential localized sources of infection, and altered mental status. Laboratory tests that may indicate sepsis are elevated or low white blood cells, elevated lactate levels, abnormal liver or kidney function, low oxygen levels, and abnormal PT/INR. Blood cultures are also obtained to identify organisms responsible for causing sepsis. Facilities and payors often use Sepsis-3 criteria to determine the degree of organ dysfunction.

Sepsis 3-Criteria

Organ dysfunction is determined by the SOFA (Sequential Organ Failure Assessment) score. The grading is based on a scale from 0-4, with 0 indicating no dysfunction. If the patient’s baseline is unknown in any of the system categories, it is assumed to be 0. The SOFA score must show a 2-point increase from the patient’s baseline values from the following categories:

  • Respiratory (P/F ratio < 400)
    • One-point increase from baseline would be P/F ratio less than 400.
    • Two-point increase from baseline would be P/F ratio less than 300.
    • Three-point increase from baseline would be P/F ratio less than 200.
    • Four-point increase from baseline would be P/F ratio less than 100.
  • Coagulation (Platelets < 150k)
    • One-point increase from baseline would be platelets less than 150.
    • Two-point increase from baseline would be platelets less than 100.
    • Three-point increase from baseline would be platelets less than 50.
    • Four-point increase from baseline would be platelets less than 20.
  • Hepatic (Bilirubin ≥ 1.2)
    • One-point increase from baseline would be bilirubin less than 1.2-1.9.
    • Two-point increase from baseline would be bilirubin 2.0-5.9.
    • Three-point increase baseline would be bilirubin 6.0-11.9.
    • Four-point increase from baseline would be bilirubin greater than 12.0.
  • Cardiovascular (Mean Arterial Pressure-MAP < 70)
    • One-point increase from baseline would be MAP less than 70mm Hg.
    • Two-point increase from baseline would be administration of Dopamine less than 5, or any dose of dobutamine to maintain MAP of 65mm HG.
    • Three-point increase from baseline would be administration of Dopamine 5.1-15, epinephrine administration of 0.1, or norepinephrine administration of 0.1 to maintain MAP of 65mm HG.
    • Four-point increase from baseline would be administration of Dopamine greater than 15, or epinephrine administration greater than 0.1, or norepinephrine administration greater than 0.1 to maintain MAP of 65mm HG.
  • Neurologic (GCS < 15)
    • One-point increase from baseline would be Glasgow Coma Score 13-14.
    • Two-point increase from baseline would be GCS score 10-12.
    • Three-point increase from baseline would be GCS 6-9.
    • Four-point increase from baseline would be GCS less than
  • Renal (Creatinine ≥ 1.2) - Sepsis 3 does not require KDIGO AKI criteria to be met, however, SOFA score for Renal is based on the following.
    • One-point increase from baseline would be creatinine less than 1.2.
    • Two-point increase from baseline would be creatinine 2.0-3.4.
    • Three-point increase from baseline would be creatinine 3.5-4.9.
    • Four-point increase from baseline would be creatinine greater than 5.0.

How is Sepsis Treated?

Treatment for sepsis may include IV antibiotics, IV fluids, supplemental oxygen when respiratory organs are involved, and close monitoring, often in an intensive care unit.

How is a Leading Query Avoided?

When querying providers to clarify sepsis, leading questions must be avoided. A leading query asks the provider to document a specific diagnosis, or directing the provider to provide a diagnosis without taking into account medical decision making. When sending a query to clarify if the patient has sepsis, it should include at least two or more clinical indicators (provider assessment and lab values), treatment given, and some degree of organ dysfunction.

Examples of appropriate questions for sepsis querying:

  • “Based on your medical judgement, are you able to determine the condition being treated based on the patient’s clinical indicators?”
  • “Based on your medical judgement, can you clarify the infectious condition being treated?” This would be used when a localized infection has been established in the medical record.

References

  • CDI Pocket Guide by Pinson & Tang-Sepsis-3
  • Guidelines for Achieving a Compliant Query Practice
  • AHA Coding Handbook
  • JAMA online Volume 315, No 8, The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis 3)
  • https://commons.wikimedia.org

For more than 30 years, HIA has been the leading provider of compliance auditscoding support services and clinical documentation audit services for hospitalsambulatory surgery centersphysician groups and other healthcare entities. HIA offers PRN support as well as total outsource support.

The information contained in this coding advice is valid at the time of posting. Viewers are encouraged to research subsequent official guidance in the areas associated with the topic as they can change rapidly.